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中国当代医药  2020, Vol. 27 Issue (27): 69-72    
  内分泌研究 本期目录 | 过刊浏览 | 高级检索 |
二甲双胍联合针刺对肥胖型PCOS糖脂代谢与脂肪因子影响的临床研究
王佳媛 马 瑶 杜维娜 王宝成 吴隆琦▲
大连市妇幼保健院生殖中心,辽宁大连 116021
Clinical study of influence of Metformin combined with acupuncture on glucolipid metabolism and adipokines in obese polycystic ovarian syndrome
WANG Jia-yuan MA Yao DU Wei-na WANG Bao-cheng WU Long-qi
Reproductive Center, Maternal and Child Health Hospital of Dalian City, Liaoning Province, Dalian 116021, China
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摘要 
目的 探讨二甲双胍联合针刺对肥胖型多囊卵巢综合征(PCOS)糖脂代谢与脂肪因子的影响。方法 选取2018年2月~2019年2月我院收治的90 例肥胖型PCOS 患者作为研究对象,按照随机数字表法分为A 组(30 例)、B 组(30 例)与C 组(例)。A 组采用二甲双胍治疗方法,B 组采用针刺治疗方法,C 组采用二甲双胍联合针刺治疗方法,比较三组的性激素水平、糖脂代谢相关指标、脂肪因子水平、妊娠率。结果 C 组治疗后的黄体生成素(LH)、卵泡生成激素(FSH)、睾酮(T)水平均低于A 组与B 组,雌二醇(E2)水平高于A 组与B 组,差异有统计学意义(P<0.05);C 组治疗后的三酰甘油(TG)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)水平均低于A 组与B 组,差异有统计学意义(P<0.05);C 组治疗后的体重指数(BMI)、腰臀比水平均低于A 组与B 组,差异有统计学意义(P<0.05);C 组的妊娠率高于A 组与B 组,差异有统计学意义(P<0.05)。结论 肥胖型PCOS 患者采用二甲双胍联合针刺治疗可有效降低体重指数,改善胰岛素水平、糖脂代谢,能够调节患者的性激素水平,促进患者妊娠。
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关键词 肥胖型多囊卵巢综合征二甲双胍针刺糖脂代谢脂肪因子    
Abstract
Objective To investigate the influence of Metformin combined with acupuncture on glucolipid metabolism and adipokines in obese polycystic ovarian syndrome (PCOS). Methods A total of 90 patients with obese PCOS who admitted in our hospital from February 2018 to February 2019 were selected as the research subjects. All selected cases were divided into group A(30 cases),group B(30 cases)and group C(30 cases)according to random number table method.Group A was treated with Metformin, group B was treated with acupuncture, and group C was treated with Metformin combined with acupuncture. The levels of sex hormones, glucolipid metabolism indexes, adipokines levels and pregnancy rates were compared among the three groups. Results After treatment, the levels of triglyceride (TG), follicle-stimulating hormone (FSH) and testosterone (T) in group C were lower than those in group A and group B, and the level of estradiol (E2) in group C after treatment was higher than that in group A and group B, the differences were statistically significant (P<0.05). After treatment, the triglyceride (TG), fasting plasma glucose (FPG) and homeostasis model assessment of insulin resistance (HOMA-IR) in group C were lower than those in group A and group B, the differences were statistically significant (P<0.05). After treatment, the body mass index (BMI) and waist-hip ratio in group C were lower than those in group A and group B, the differences were statistically significant (P<0.05). The pregnancy rate of group C was higher than that of group A and group B, the difference was statistically significant (P<0.05). Conclusion Metformin combined with acupuncture in the treatment of obese PCOS patients can decrease BMI, improve the level of insulin and glucolipid metabolism, regulate the levels of sex hormones, and promote the pregnancy.
Key wordsObese polycystic ovarian syndrome    Metformin    Acupuncture    Glucolipid metabolism    Adipokines
    
基金资助:
辽宁省大连市医学科学研究计划项目(1711070)
通讯作者: 吴隆琦(1959-),女,本科,主任医师,研究方向:生殖内分泌   
作者简介: 王佳媛(1986-),女,黑龙江肇源人,硕士,主治医师,研究方向:生殖内分泌
引用本文:   
王佳媛;马 瑶;杜维娜;王宝成;吴隆琦. 二甲双胍联合针刺对肥胖型PCOS糖脂代谢与脂肪因子影响的临床研究[J]. 中国当代医药, 2020, 27(27): 69-72.
WANG Jia-yuan MA Yao DU Wei-na WANG Bao-cheng WU Long-qi▲. Clinical study of influence of Metformin combined with acupuncture on glucolipid metabolism and adipokines in obese polycystic ovarian syndrome. 中国当代医药, 2020, 27(27): 69-72.
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