Objective To explore the application effect of "Internet + health management" model in young and middleaged obese people. Methods The clinical data of 118 young and middle-aged obese patients who had physical examination in our hospital from January 2015 to December 2016 were retrospectively selected, with body mass index (BMI)≥28 kg/m2, aged 18 to 59 years old, and a self-controlled cohort was used, intervened with the "Internet + health management" model to observe the weight management effect of obese people before and after intervention. Results The health management model was used to manage weight for 118 young and middle-aged obese persons for 12 months. The body weight, hip circumference, waist circumference, BMI at 6 months and 12 months and triglycerides at 12 months after intervention were lower than those before intervention, and the differences were statistically significant(P<0.05). The triglycerides, cholesterol, fasting blood glucose, systolic blood pressure, and diastolic blood pressure at 6 months after intervention were lower than those before intervention, but the differences were not statistically significant(P>0.05). The cholesterol, systolic blood pressure and diastolic blood pressure at 12 months after intervention were lower than those before intervention, the differencea were statistically significant (P<0.05). The body weight, hip circumference, waist circumference, BMI, triglyceride, cholesterol and diastolic blood pressure values at 12 months after intervention were lower than those at 6 months after intervention, the differences were statistically significant (P<0.05).Conclusion The "Internet + health management" model has a good effect on the weight management of young and middle-aged obese people and is worthy of clinical application.