Objective To evaluate the effect of low-dose Aspirin on uterine arterial blood flow and endometrium after transcervical resection of adhesion. Methods PubMed, Web of Science, MEDLINE, CNKI, Wanfang and other databases were searched, the retrieval time was from the database construction to December 2019, strict inclusion and exclusion criteria were formulated, quality evaluation of included literature was conducted, and Review Manager 5.3 software was used for Meta-analysis. Results Finally, 7 random control trial (RCT) articles were included. The results of Metaanalysis showed that the uterine artery resistance index (RI) in the experimental group was lower than that in the control group, and the difference was statistically significant (WMD=-0.17, 95%CI[-0.19, -0.14], P<0.000 01). The pulsatility index (PI) in the experimental group was lower than that in the control group, and the difference was statistically significant (WMD=-0.33, 95%CI[-0.49, -0.17], P<0.0001). The endometrial vascularization index (VI) in the experimental group was higher than that in the control group, and the difference was statistically significant (WMD=1.01,95%CI[0.46, 1.55], P=0.0003). The blood flow index (FI) and vascularized blood flow index (VFI) in the experimental group were higher than those in the control group, and the differences were statistically significant (WMD=4.53, 95%CI[3.45,5.61],P<0.000 01;WMD=0.30,95%CI[0.24,0.35],P<0.000 01).The proportion of type A endometrium in the experimental group was higher than that in the control group, and the difference was statistically significant (OR=3.01, 95%CI [1.38, 6.60], P=0.006). Conclusion The application of low-dose Aspirin after transcervical resection of adhesion can improve the uterine artery blood flow, increase endometrium perfusion and the proportion of type A endometrium, promote the repair of endometrium.
张 欢;杨贵霞; 马明明. 小剂量阿司匹林对宫腔粘连分离术后子宫动脉血流及子宫内膜影响的Meta分析[J]. 中国当代医药, 2020, 27(27): 12-15.
ZHANG Huan YANG Gui-xia▲ MA Ming-ming. Meta-analysis of the effect of low-dose Aspirin on uterine arterial blood flow and endometrium after transcervical resection of adhesion. 中国当代医药, 2020, 27(27): 12-15.
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