Clinical features of patients with different pathological types of lung cancer and brain metastases and the risk factors of cerebral hemorrhage
HONG Liang1 HUANG Xing-zhi2 GUO Jian-rong3
1. Department of Thoracic Surgery, General Hospital of Pingxiang Mining Group Co., Ltd., Jiangxi Province, Pingxiang 337000, China;
2. Department of Oncology, Pingxiang People′s Hospital, Jiangxi Province, Pingxiang 337000, China;
3. Department of Surgery, Pingxiang Ganxi Cancer Hospital, Jiangxi Province, Pingxiang 337000, China
Abstract:Objective To investigate the clinical features of different pathological types of lung cancer and brain metastases, and to analyze the risk factors of cerebral hemorrhage. Methods The clinical data of 370 patients with lung cancer and brain metastases who were treated in the General Hospital of Pingxiang Mining Group Co., Ltd. from May 2017 to May 2019 were retrospectively analyzed. The clinical features of different pathological types of lung cancer and brain metastases and the influencing factors of cerebral hemorrhage were analyzed. Results There were significantly statistical differences in the distribution of intracranial lesions, combined hemorrhage and density of lesion among the patients with different pathological types (squamous cell carcinoma, adenocarcinoma, small cell carcinoma, large cell carcinoma, adenosquamous carcinoma) of lung cancer and brain metastases (P<0.05). The patients were divided into the hemorrhage group (n=154) and the non-hemorrhage group (n=216) according to the hemorrhage of patients. The results of single-factor analysis showed that the proportions of high density or mixed density of multiple lesions and tumor in the hemorrhage group were higher than those in the non-hemorrhage group, the differences were statistically significant(P<0.05). Multiple-factor analysis showed that the high density or mixed density of multiple lesions (β=1.959, OR=7.091, 95%CI=4.442-11.320) and tumor (β=0.740, OR=2.095, 95%CI=1.376-3.190) were the risk factors of cerebral hemorrhage in patients with lung cancer and brain metastases (P<0.05). Conclusion The lung cancer patients with different pathological types have different clinical features of brain metastases, and the risk of cerebral hemorrhage can be estimated based on the clinical features of patients.
洪亮;黄行志;郭建荣. 不同病理类型肺癌脑转移患者的临床特征及合并脑出血的危险因素分析[J]. 中国当代医药, 2020, 27(26): 77-80.
HONG Liang; HUANG Xing-zhi; GUO Jian-rong. Clinical features of patients with different pathological types of lung cancer and brain metastases and the risk factors of cerebral hemorrhage. 中国当代医药, 2020, 27(26): 77-80.