Effect of gender and abnormal blood glucose on cognitive function with schizophrenia patients
LING Han1 DENG You-mei2 WANG Fu-rui1
1. Department of Psychiatry, Zhaoqing Third People′s Hospital, Guangdong Province, Zhaoqing 526060, China;
2. Department of Psychiatry, Zhaoqing Third People′s Hospital, Guangdong Province, Zhaoqing 526060, China
Abstract：Objective To investigate the effect of gender and abnormal blood glucose on cognitive function with schizophrenia patients. Methods A total of 100 cases schizophrenia patients were collected from April 2018 to April 2019 in our hospital, according to whether combined type 2 diabetes mellitus ,they were divided into with diabetes mellitus group (50 cases, 28 cases men, 22 cases were women) and simple group (50 cases, 30 cases men, 20 cases were women). The levels of low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C),glycosylated hemoglobin (HbA1c) and fasting blood glucose (FPG) were compared between the two groups. A repetitive set of neuropsychological status tests was used to assess the patients′ cognitive function. Results There were no significant differences in LDL-C and HDL-C between the two groups (P＞0.05); the levels of FPG and HbA1c in men and women in the group with diabetes were respectively higher than those of the men and women in the simple group, with statistically significant differences (P＜0.05); the levels of FPG and HbA1c of men in the group with diabetes were increased than those of the women in the same group, with statistically significant differences (P＜0.05); the delay memory attention language visual span and immediate memory score of men in the group with diabetes were lower than those of the men in the simple group, with statistically significant differences (P＜0.05); the attention and immediate memory of women in the group with diabetes were lower than those of the women in the simple group, with statistically significant differences (P＜0.05); the cognitive function scores of the men in the group with diabetes were lower than those of the women in the same group, with statistically significant differences (P＜0.05); the visual span and immediate memory scores of the men in simple group were lower than those of the women in the same group,with statistically significant differences (P＜0.05); Spearman correlation showed that fasting blood glucose was negatively correlated with attention in male schizophrenic patients with diabetes, with statistically significant difference (r=-0.32, P=0.000); but there were no correlations between the delayed recall memory, language, visual span, immediate memory and the FPG (P＞0.05); There were no correlations between the FPG of the women schizophrenic patients with diabetes and the delayed recall memory, attention, language, visual span, immediate memory (P＞0.05). Conclusion Patients with abnormal blood glucose may aggravate the cognitive impairment in schizophrenics, especially in men.
Rajkumar AP，Horsdal HT，Wimberley T，et al.Endogenous and antipsychotic -related risks for diabetes mellitus in young people with schizophrenia：a danish population-based dohort study[J].Am J Psychiatry，2017，174（7）：686-694.
Ish y PL，Knop FK，Broberg BV，et al.Effect of GLP-1 receptor agonist treatment on body weight in obese antipsychotic-treated patients with schizophrenia：a randomized，placebo-controlled trial[J].Diabetes Obes Metab，2017，9（2）：167-171.
[12]
Rietschel L，Lambert M，Karow A，et al.Clinical high risk for psychosis：gender differences in symptoms and social functioning[J].Early Interv Psychiatry，2017，11（4）：306-313.
Hjorth P，Espensen CH，Madsen NJ，et al.Reducing the risk of type 2 diabetes in nonselected outpatients with schizophrenia：a 30-month program[J].J Psychiatr Pract，2018，24（1）：21-31.
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