姜黄素在治疗骨性关节炎过程中对关节软骨和滑膜细胞的作用机制

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Abstract

Curcumin is a non-steroidal anti-inflammatory drug that has a wide range of preventive and therapeutic effects on a variety of diseases and can effectively remove free radicals.Its antioxidant activity and anti-inflammatory effects have attracted wide attention.Curcumin can participate in the development of osteoarthritis by activating or inhibiting multiple signaling pathways, inhibiting chondrocyte apoptosis and degradation of chondrocyte extracellular matrix, reducing the production of various inflammatory factors, promoting chondrocyte autophagy and inhibition proliferation of synovial cells and release of inflammatory factors.However, the signaling pathway of curcumin in the treatment of osteoarthritis has not been fully elucidated.Based on this, this paper reviews the molecular mechanisms of curcumin in the treatment of osteoarthritis at home and abroad in recent years.

Key words： Curcumin Osteoarthritis Articular cartilage Synovium Signal pathway

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[11]	李晓东.姜黄素通过ERK1/2 信号通路调节软骨细胞自噬水平机理的研究[D].上海：上海交通大学，2017.
[15]	Rahman I.Antioxidant therapeutic advances in COPD[J].Ther Adv Respir Dis，2008，2（6）：351-374
[17]	陈志强，莫曾南，揭晓.姜黄素对前列腺增生动物模型PCNA、Ki67、bcl-2 和bax 表达的影响[J].中药药理与临床，2008，24（1）：36-38.
[18]	蔡辉，郑召岭，商玮，等.姜黄素对佐剂型关节炎大鼠滑膜细胞核转录因子-κB 表达的影响[J].中国中医急症，2009，18（3）：425-426.
[10]	王健，马捷，顾剑华，等.姜黄素抑制大鼠创伤性骨关节炎模型中软骨细胞核因子κB P65 核转位的实验研究[J].中国组织工程研究，2016，20（15）：2163-2170.
[1]	Cheng TH，Yoon SH，Lee P，et al.Knee synovial fluid complement C3-beta chain levels correlate with clinical symptoms of knee osteoarthritis[J].Int J Rheum Dis，2020，23（4）：569-575.
[2]	Vakharia RM，Roc he MW，Alcerro JC，et al.The Current Status of Cell-Based Therapies for Primary Knee Osteoarthritis[J].Orthop Clin North Am，2019，50（4）：415-423.
[7]	李旭升，陈慧，甄平，等.JAK2/STAT3 信号通路介导姜黄素在骨性关节炎软骨细胞代谢中的影响[J].中国骨伤，2016，29（12）：1104-1109.
[8]	马勇，王礼宁，郭杨，等.姜黄素通过调节Wnt/β-catenin信号通路促进软骨细胞增殖的研究[J].广州中医药大学学报，2017，34（1）：90-95.
[9]	舒子震，吴向阳.姜黄素对KOA 模型大鼠关节软骨Wnt信号通路的影响[J].医药前沿，2019，9（17）：13-14.
[3]	Wallace IJ，Worthington S，Felson DT，et al.Knee osteoarthritis has doubled in prevalence since the mid-20thcentury[J].Proc Natl Acad Sci USA，2017，114（35）：9332-9336.
[4]	Zheng Q.Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk[J].Osteoarthritis Cartilage，2016，24（1）：158-168.
[5]	Park SK，Dahmer MK，Quasney MW.MAPK and JAK-STAT signaling pathways are involved in the oxidative stress-induced decrease in expression of surfactant protein genes[J].Cell Physiol Biochem，2012，30（2）：334-346.
[6]	Nakayamada S，Kubo S，Iwata S，et al.Erratum to：Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis[J].Bio Drugs，2016，30（5）：407-419.
[12]	Shakibaei M，Mobasheri A，Buhrmann C.Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytesin vitro[J].Genes Nutr，2011，6（2）：171-179.
[13]	Wu TJ，Lin CY，Tsai CH，et al.Glucose suppresses IL-1beta-induced MMP-1 expression through the FAK，MEK，ERK，and AP-1 signaling pathways[J].Environ Toxicol，2018，33（10）：1061-1068.
[14]	Kraft AD，Resch JM，Johnson DA，et al.Activation of the Nrf2-ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1[J].Exp Neurol，2008，207（1）：61-69.
[16]	Zhang G，Cao J，Yang E，et al.Curcumin improves age-related and surgically induced osteoarthritis by promoting autophagy in mice[J].Biosci Rep，2018，38（4）：1691.
[19]	Dai Q，Zhou D，Xu L，et al.Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats[J].Drug Des Devel Ther，2018，12：4095-4105.
[20]	邱艳，商玮，赵智明，等.姜黄素对佐剂性关节炎大鼠滑膜OPG 和RANKL 蛋白表达的影响[J].中国免疫学杂志，2014，（11）：1490-1493.
[21]	Mun SH，Kim HS，Kim JW，et al.Oral administration of curcumin suppresses production of matrix metalloproteinase （MMP）-1 and MMP-3 to ameliorate collagen-induced arthritis：inhibition of the PKCdelta/JNK/c -Jun pathway[J].J Pharmacol Sci，2009，111（1）：13-21.
[22]	Usami Y，Gunawardena AT，Iwamoto M，et al.Wnt signaling in cartilage development and diseases：lessons from animal studies[J].Lab Invest，2016，96（2）：186-196.
[23]	Yuan X，Liu H，Huang H，et al.The Key Role of Canonical Wnt/β-catenin Signaling in Cartilage Chondrocytes[J].Curr Drug Targets，2016，17（4）：475-484.
[24]	代万武，张波，刘俊佳，等.无翅型MMTV 整合位点家族蛋白通路在调控脂肪干细胞成骨及成软骨分化中的分子机制[J].中华实验外科杂志，2019，36（9）：1634-1637.
[25]	Schmalhofer O，Brabletz S，Brabletz T.E-cadherin，betacatenin，and ZEB1 in malignant progression of cancer[J].Cancer Metastasis Rev，2009，28（1-2）：151-166.
[26]	Li X，He P，Li Z，et al.Interleukin1betamediated suppression of microRNA27a3p activity in human cartilage via MAPK and NF-κB pathways：A potential mechanism of osteoarthritis pathogenesis[J].Mol Med Rep，2018，18（1）：541-549.
[27]	中华医学会骨科学分会关节外科学组.骨关节炎诊疗指南（2018年版）[J].中华骨科杂志，2018，38（12）：705-715.
[28]	孙达锋，王黎明，徐燕，等.姜黄素对兔骨关节炎软骨组织学及CL-2、Mmp9、COX-2、IKKβ、NF-κb mRNA 表达的影响[J].现代生物医学进展，2010，10（11）：2045-2048.
[29]	Que LL，Wang HX，Cao BS，et al.The regulation and functions of transcription factor Nrf2 in cancer chemoprevention and chemoresistance[J].J Chin Pharm Sci，2011，20（1）：5-19.
[30]	宋永周，健关，明李，等.Nrf2 介导姜黄素对软骨细胞氧化应激损伤的保护作用[J].中国组织工程研究，2015，19（51）：8218-8222.
[31]	Williamson TP，Johnson DA，Johnson JA.Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTPmediated neurotoxicity[J].Neurotoxicology，2012，33（3）：272-279.
[32]	Jiang C，Luo P，Li X，et al.Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation[J].Cell Stress Chaperones，2020，25（3），395-406.
[33]	Kloesch B，Becker T，Dietersdorfer E，et al.Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes[J].Int Immunopharmacol，2013，15（2）：400-405.
[34]	Goel BCA.A Randomized，Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis[J].Phytother Res，2012，26（11）：1719-1725.
[35]	Henrotin Y，Malaise M，Wittoek R，et al.Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain：a double-blind multicenter randomized placebo controlled three-arm study[J].Arthritis Res Ther，2019，21（1）：179.
[36]	Appelboom T，Maes N，Albert A.A New Curcuma Extract（Flexofytol®）in Osteoarthritis：Results from a Belgian Real-Life Experience[J].Open Rheumatol J，2014，8（1）：77-81.
[37]	Breucker SD，Rouvière H，Mélot C，et al.Flexofytol®（A Belgian Curcumin Extract） for the Treatment of Aged Patients with Osteoarthritis and Comorbidity [J].Open J Rheumatol Autoimmune Dis，2017，7（4）：167-177.
[38]	Haroyan A，Mukuchyan V，Mkrtchyan N，et al.Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis：a comparative，randomized，double-blind，placebo-controlled study[J].BMC Complement Altern Med，2018，18（1）：7.
[39]	Posadzki P，Watson LK，Ernst E.Adverse effects of herbal medicines：an overview of systematic reviews[J].Clin Med，2013，13（1）：7-12.
[40]	Liang HP，Yan J，Liu DB，et al.The Clinical Applications of Curcumin：Current State and the Future[J].Curr Pharm Des，2013，19（11）：2011-2031.