|
Abstract Objective To explore the influencing factors of the prognosis of patients with local recurrence after breast cancer surgery.Methods The clinical data of 98 patients with local recurrence of breast cancer after surgery in the Department of General Surgery,Jingzhou Third People′s Hospital from January 2017 to October 2019 were retrospectively analyzed.Their baseline data were collected,including age,menstrual status,postoperative tumor-free survival interval,adjuvant radiotherapy,adjuvant chemotherapy,local recurrence type,progesterone receptor,lymph node metastasis,clinical stage of primary tumor,maximum diameter of chest wall recurrence,pathological type and follow-up operation.According to the prognosis of patients within 6 months,they were divided into survival group (n=79) and death group(n=19).The clinical data of the two groups were compared,and the influencing factors of prognosis were analyzed by COX model.Results In the 98 patients,79 patients (80.61%) survived and 19 patients (19.39%) died.The results of univariate analysis showed that the differences in tumor-free survival interval,local recurrence type,lymph node metastasis,follow-up surgery,and prolactin (PRL) and carcinaombryonic antigen (CEA) levels between the death group and the survival group were statistically significant (P＜0.05).The result of COX regression model analysis showed that,tumor-free survival interval ＜2 years (β=1.412,OR=4.104,95%CI=1.340-12.569),diffuse recurrence of chest wall (β=1.398,OR=4.047,95%CI=1.701-9.629),lymph node metastasis (β=1.367,OR=3.924,95%CI=1.407-10.944),PRL≥457.35 mIU/mL (β=2.420,OR=11.246,95%CI=1.889-66.952),and CEA≥1.35 ng/mL (β=2.676,OR=8.276,95%CI=2.346-89.880) were risk factors of death (P＜0.05).Follow-up surgery (β=-0.152,OR=0.859,95%CI=0.741-0.996) reduced the risk of death (P ＜0.05).Conclusion The prognosis of patients with local recurrence after breast cancer surgery is related to tumor free survival time,local recurrence type,lymph node metastasis and follow-up operation.
|
