慢性肾脏病患者亚临床甲状腺功能减退症的研究进展

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Abstract The prevalence and incidence of chronic kidney disease (CKD) is increasing,which has become one of the serious public health problems in the world.During the progression of CKD,thyroid hormone synthesis,secretion,decomposition and metabolism are often accompanied by abnormalities,characterized by hypothyroidism,which is common in low T3 syndrome (LT3S) and subclinical hypothyroidism (SCH).The research results show that CKD and hypothyroidism may influence each other.CKD can cause hypothyroidism,and hypothyroidism can also lead to the decrease of renal function in patients with CKD.In CKD and end-stage renal disease (ESRD),SCH may be associated with higher cardiovascular morbidity and all-cause mortality,which is a predictor of adverse outcomes.However,there are fewer studies on the SCH epidemiological investigation in patients with CKD.Up to now,the safety and efficacy of thyroxine replacement therapy are still controversial.In this paper,the mechanism of interaction between CKD and hypothyroidism,the prevalence of SCH in patients with CKD,and the influence of thyroid replacement therapy on the prognosis of patients with CKD were described.

Key words： Chronic kidney disease End-stage renal disease Subclinical hypothyroidism Hypothyroidism Thyroid hormone replacement therapy

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	TAN Ni
	SHI Lei

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TAN Ni,SHI Lei. Research progress of subclinical hypothyroidism in patients with chronic kidney disease[J]. 中国当代医药, 2021, 28(7): 29-32.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I7/29

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