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| Application of different marker differences in predicting the risk of obesity asthma |
| YU Xiao-mei1 WANG Xin2 YE Li-wen3 ZHAO Long2 HAN Wei2▲ |
1.Department of Clinical Medicine, Qingdao University, Shandong Province, Qingdao 266071, China;
2.Department of Respiration, Qingdao Municipal Hospital Affiliated to Qingdao University, Shandong Province, Qingdao 266071,China;
3.Department of Clinical Medicine, Taishan Medical University, Shandong Province, Tai′an 271000, China |
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Abstract Objective To elucidate the differences in characteristic biomarkers among different phenotypic obesity asthma, and to screen out sensitive and accurate predictive markers for disease, so as to provide objective evidence for the accurate treatment of obesity asthma.Methods A total of 196 patients with asthma in the Department of Respiratory Medicine of the Eastern Hospital of Qingdao Municipal Hospital from May 2017 to May 2018 were selected as subjects, including 70 patients with obese asthma (body mass index [BMI]≥28 kg/m2) and 126 patients with general asthma (BMI<24 kg/m2).According to fractional exhaled nitric oxide (FeNO)≥25 ppb, obese asthma patients were divided into high FeNO group (21 cases) and low FeNO group (49 cases).The differences in these aspects were compared of different phenotypic asthma groups such as immunoglobulin E (IgE), metabolic indicators (blood sugar, total cholesterol [TC], triglyceride [TG], low density lipoprotein cholesterol [LDL-C], high density lipoprotein cholesterol [HDL-C],uric acid [UA]), lung functions (1 second forced expiratory volume [FEV1]/forced vital capacity [FVC], FEV1 as a percentage of predicted value [FEV1%], FVC as a percentage of predicted value [FVC%], FVC improvement value, FEV1 absolute increase) and asthma control assessment (ACT) score.Results The levels of IgE, TC and TG in the obese asthma group were higher than those in the general asthma group, but the differences were not statistically significant (P>0.05).The levels of blood glucose, LDL-C and UA in the obese asthma group were higher than those in the general asthma group, and the HDL-C level was lower than that in the general asthma group, with statistically significant differences (P<0.05).The FEV1/FVC, FEV1% and ACT scores of the obese asthma group were lower than those of the general asthma group, and the differences were statistically significant (P<0.05).There were no significant differences in FVC%, FVC improvement value, and FEV1 absolute increase between the obese asthma group and the general asthma group (P>0.05).The levels of IgE, blood glucose,TC, TG, LDL-C and UA in the low FeNO group were higher than those in the high FeNO group, the HDL-C level was lower than that in the high FeNO group, but the differences were not statistically significant (P>0.05).The FEV1/FVC,FEV1%, FVC%, and ACT scores in the low FeNO group were lower than those in the high FeNO group, and the differences were statistically significant (P<0.05).The FVC improvement value and the FEV1 absolute increase in the low FeNO group were lower than those in the high FeNO group, but the differences were not statistically significant (P>0.05).Conclusion Metabolic indicators including blood glucose, LDL-C, HDL-C and UA can be used as biomarkers to predict the risk of obesity asthma.Obesity asthma with low FeNO has poor lung function and control, which needs more medical intervention.
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