正常妊娠妇女不同时期凝血四项、D-二聚体及抗凝血酶Ⅲ的变化及临床意义

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Abstract Objective To explore the changes and clinical significance of blood coagulation four items, D-dimer (D-D)and antithrombin Ⅲ (AT-Ⅲ) in normal pregnant women at different stages. Methods A total of 556 single pregnant women without childbirth history (135 cases in the early pregnancy, 145 cases in the second trimester, 140 cases in the third trimester, and 136 cases in the expectant period) undergoing the prenatal examination in Liuzhou Maternal and Child Health Hospital from March 2018 to March 2019 and 150 non-pregnant women were selected as the research objects. The differences of blood coagulation four items (prothrombin time [PT], activated partial thromboplastin time[APTT], thrombin time [TT], fibrinogen [FIB]), D-D and AT-Ⅲwere detected among them. Results The PT, APTT and TT of women in the early pregnancy, the second trimester, the third trimester and the expectant period were shorter than those of non-pregnant women, FIB and D-D were higher than those of non-pregnant women, and the differences were statistically significant (P＜0.05). The FIB and D-D of women in the second trimester, the third trimester and expectant period were higher than those of women in the early pregnancy, and the D-D levels of women in the third trimester and expectant period were higher than those of women in the second trimester, with statistically significant differences (P＜0.05). The AT-Ⅲof women in the second trimester, third trimester and expectant period was lower than that of the non-pregnant women, the AT-Ⅲof women in the third trimester and expectant period was lower than that of women in the early pregnancy and in the second trimester, statistically significant differences (P＜0.05). There was no significant difference in AT-Ⅲbetween the women in the early pregnancy and non-pregnant women, and there were no significant differences in FIB, D-D, AT-Ⅲbetween the women in the third trimester and in the expectant period(P＞0.05). Conclusion Changes of blood coagulation function in normal pregnant women during different periods of pregnancy may indicate that the body is in a hypercoagulable state, and the fibrinolytic function is enhanced.

Key words： Pregnant woman Blood coagulation function D-dimer Antithrombin Ⅲ

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	XIAN Xiao-ying
	CHEN Hua-gan

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XIAN Xiao-ying,CHEN Hua-gan. Changes and clinical significance of blood coagulation four items, Ddimer and antithrombin Ⅲin normal pregnant women at different stages[J]. 中国当代医药, 2020, 27(6): 170-173.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I6/170

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