特布他林与噻托溴铵治疗慢性阻塞性肺疾病急性加重期患者的临床效果

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Abstract Objective To investigate the clinical effect of Terbutaline and Tiotropium Bromide in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods Retrospective analysis was performed on 90 cases of COPD patients admitted and treated in our hospital from January 2017 to February 2019 were selected as research objects,and they were divided into group A,B and C according to different treatment methods,with 30 cases in each group.Tiotropium Bromide was used in group A,Terbutaline in group B,and Terbutaline combined with Tiotropium Bromide in group C.The total therapeutic efficiency of the three groups was compared.And the pulmonary function indicators of the three groups were compared,such as the forced expiratory volume in the first second (FEV1),forced lung capacity (FVC),and the forced expiratory volume per second vs.forced vital capacity ratio(FEV1/FVC).The blood gas analysis indexs of the three groups were compared,such as hydrogen ion concentration index (pH value),partial arterial blood pressure of carbon dioxide (PaCO2),blood oxygen partial pressure (PaO2).The adverse reactions of the three groups were compared.Results There was no statistically significant difference in total effective rate of clinical treatment between group A and group B (P>0.05).The total effective rate of clinical treatment of group C was higher than that of group A and B,and the differences were statistically significant (P<0.05).After treatment,FEV1,FVC,FEV1/FVC in group A showed no statistically significant difference compared with group B (P>0.05).After treatment,FEV1,FVC and FEV1/FVC in group C were higher than those in group A and group B,with statistically significant differences (P<0.05).There was no statistically significant difference in pH value,PaCO2and PaO2between group A and group B after treatment (P>0.05).After treatment,PaO2in group C was higher than that in group A and group B,with statistically significant differences (P<0.05).After treatment,PaCO2in group C was lower than that in group A and group B,with statistically significant difference (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions among the three groups (P>0.05).Conclusion Combining Tiotropium Bromide with Terbutaline can improve the clinical therapeutic effect,improve the pulmonary function and ensure the safety of treatment for patients with acute exacerbation of COPD.

Key words： Terbutaline Tiotropium Bromide Acute exacerbation of chronic obstructive pulmonary disease Pulmonary function Blood gas analysis

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	LU Yu-lin
	YUAN Hua-bao
	LIU Xian-kui

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LU Yu-lin,YUAN Hua-bao,LIU Xian-kui. Clinical effect of Terbutaline and Tiotropium Bromide in the treament of patients with acute exacerbation of chronic obstructive pulmonary disease[J]. 中国当代医药, 2020, 27(2): 42-45.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I2/42

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