子痫前期患者检测凝血、抗凝和纤溶实验室指标的价值分析

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Abstract Objective To observe the changes of blood coagulation, anticoagulation and fibrinolysis indicators in patients with pregnancy-induced hypertension at different degrees and their effects on maternal and fetal outcomes.Methods A retrospective analysis of clinical data of 130 pregnant women with pregnancy-induced hypertension during the delivery from August 2017 to August 2018 in Shenzhen Maternal and Child Health Care Hospital was made, including 41 cases gestational hypertension, 51 cases mild preeclampsia, and 38 cases severe preeclampsia.Meanwhile,another 40 cases of healthy pregnant women who delivered in Shenzhen Maternal and Child Health Care Hospital were enrolled.The prothrombin time (PT), activated partial thrombin time (APTT), antithrombin-Ⅲ(AT-Ⅲ), D-dimer (DD), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), fibrinogen (FIB), and fibrinogen degradation products (FDP) levels of gestational hypertension in different periods were analyzed.The occurrence of adverse maternal outcomes in pregnancy-induced hypertension women such as placental abruption, postpartum hemorrhage, fetal growth restriction, intrauterine distress, premature delivery, and stillbirth was recorded.Results The PT and APTT in pregnant women with gestational hypertension were shorter than those in healthy pregnant women, the level of AT-Ⅲwas lower than that in the healthy pregnant women, and the levels of D-D, t-PA, PAI-1, FIB and FDP were higher than those in the healthy pregnant women, with statistically significant differences (P＜0.05).In pregnant women at different stages of hypertensive gestation, the PT and APTT in severe preeclampsia were shorter than those in mild preeclampsia and gestational hypertension, the level of AT-Ⅲin severe preeclampsia was lower than that in mild preeclampsia and gestational hypertension, and the levels of D-D, PAI-1, FDP and FIB were higher than those in mild preeclampsia and gestational hypertension, with statistically significant differences (P＜0.05).The level of maternal AT-Ⅲin patients with adverse maternal and infant outcomes was lower than that without adverse maternal outcome, the level of PAI-1 was higher compared with that without adverse outcomes, with statistically significant differences (P＜0.05).Conclusion Women with pregnancy-induced hypertension, especially in preeclampsia, is abnormally hypercoagulable.Early detection of blood coagulation, anticoagulation and fibrinolysis can prevent the occurrence of adverse maternal and child outcomes.

Key words： Coagulation indicator Fibrinolysis indicator Preeclampsia Maternal and child outcomes

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	Articles by authors
	LIN Bing-yin
	LUO Xiao-yan
	FANG Zhou-bin
	ZHU Yan

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LIN Bing-yin,LUO Xiao-yan,FANG Zhou-bin, et al. Value analysis of laboratory indicators for blood coagulation, anticoagulation and fibrinolysis in patients with preeclampsia[J]. 中国当代医药, 2019, 26(12): 26-29.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I12/26

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