|
|
|
| Characteristics of lymphocyte subsets in 114 children with moderate to severe systemic lupus erythematosus and follow-up after treatment |
| LIU Ting1 SUN Guang-chao2 ZENG Hua-song2▲ |
| 1. Department of Pediatrics, Maternal and Child Health Care Hospital of Zhuhai City in Guangdong Province, Zhuhai 519000,China;2.Women′s and Children′s Medical Center of Guangzhou City,Guangdong Province,Guangzhou 510000,China |
|
|
|
|
Abstract Objective To analyze the clinical manifestations of lymphocyte subsets in systemic lupus erythematosus(SLE) children with moderate or severe disease activity, and to compare their corresponding changes after 6 months of treatment. Methods Clinical data of 114 patients with moderate and SLE disease activity index (SLEDAI) in Women′s and Children′s Medical Center of Guangzhou City from January 2013 to January 2018 were retrospectively analyzed.The immunological indicators and lymphocyte subgroup classification results were analyzed. According to the SLEDAI,patients were divided into the moderate activity group (MAG) and the severe activity group (SAG) for further contrast,and the SLEDAI, lymphocyte subsets and immunological indices after 6 months of treatment were compared and statistically analyzed. Results The average age of 114 children was (10.56±2.65) years old, with a 1∶3.56 male-female proportion. The score of SLEDAI was (15.21±3.95) points, with 49 MAG patients and 65 SAG patients. The complement C3 and C4 of MAG were significantly lower than that of SAG (P＜0.05). The NK cells (CD16+CD56+) of MAG was significantly higher than those of SAG (P＜0.05), and CD4+/CD8+ of the SAG were significantly higher than those of MAG(P＜0.05). The SLEDAI score after 6 months of treatment was significantly lower than that at the first visit (P＜0.05), and the level of IgG, IgA and IgE were significantly lower (P＜0.05), and CD19+ were lower, while C4 and CD8+ were significantly higer (P＜0.05). Conclusion Immunological indicators combined with lymphocyte subgroup classification can partly reflects the clinical treatment effect of SLE children patients, and has a good correlation with SLEDAI,which is worth promoting in clinical work.
|
|
|
|
|
|
|
|
|
