奥美拉唑为基础的三联疗法对幽门螺杆菌感染胃溃疡患者血清炎症因子及胃肠激素的影响

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Abstract Objective To investigate the effect of omeprazole-based triple therapy on serum inflammatory factors and gastrointestinal hormones in patients with Helicobacter pylori-infected gastric ulcer.Methods A total of 84 patients with Helicobacter pylori-infected gastric ulcer admitted to our hospital from November 2015 to October 2017 were selected and divided into reference group and experimental group by random number table method,with 42 cases in each group.The reference group was treated with omeprazole and amoxicillin,while the experimental group was treated with omeprazole-based triple therapy.The therapeutic effects of the two groups of patients,as well as the changes of serum inflammatory factors and gastrointestinal hormone levels were studied and compared.Results The total effective rate in the experimental group was significantly higher than that in the reference group,the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference between the two groups(P＞0.05).After treatment,the levels of serum inflammatory factors in the two groups were lower than those before treatment,and the levels of serum inflammatory factors in the experimental group were significantly lower than those in the reference group,the differences were statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in gastrointestinal hormone levels between the two groups before and after treatment(P＞0.05).After treatment,the gastrointestinal hormone levels in the two groups were lower than those before treatment,and the gastrointestinal hormone levels in the experimental group were significantly lower than those in the reference group,the differences were statistically significant(P＜0.05).Conclusion Omeprazole-based triple therapy can effectively improve the levels of serum inflammatory factors and gastrointestinal hormone in the treatment of patients with Helicobacter pylori-infected gastric ulcer,which is beneficial to the recovery of the ulcer.

Key words： Omeprazole Triple therapy Helicobacter pylori infection gastric ulcer Serum inflammatory factors Gastrointestinal hormones

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	ZHAO Jing
	YI Jing

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ZHAO Jing,YI Jing. Effects of omeprazole-based triple therapy on serum inflammatory factors and gastrointestinal hormones in patients with Helicobacter pylori-infected gastric ulcer[J]. 中国当代医药, 2018, 25(23): 73-75.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I23/73

[1]	刘素芳.以雷贝拉唑和奥美拉唑为基础的三联疗法治疗胃溃疡的疗效比较[J].北方药学，2017，14（11）：94.
[2]	孙杰连.埃索美拉唑与奥美拉唑三联疗法治疗幽门螺杆菌相关性胃溃疡的疗效对比[J].河南医学研究，2015，24（1）：92-93.
[3]	曲恒怡，王雪萍，孙华波，等.幽门螺杆菌感染对胃溃疡患者胃蛋白酶原及胃肠动力状态的影响研究[J].中华医院感染学杂志，2017，27（10）：2183-2185，2209.
[4]	赖人旭，任江南，苟新敏，等.铝碳酸镁片联合埃索美拉唑肠溶片治疗幽门螺杆菌感染合并活动性胃溃疡的临床研究[J].中国临床药理学杂志，2017，33（19）：1868-1870.
[5]	王克儒，王先安.幽门螺杆菌感染对中老年胃溃疡患者心理状态的影响[J].中国健康心理学杂志，2017，25（5）：680-683.
[6]	黄玉林.消化性溃疡患者非甾体类抗炎药服用史和幽门螺杆菌感染的协同致病性[J].中国老年学杂志，2018，38（2）：389-390.
[7]	秦耿，王慧芬，白如雪，等.消化性溃疡临床病理特征及其与幽门螺杆菌感染的关系[J].中国医药，2017，12（10）：1549-1551.
[8]	杨志平，刘为，关晓辉，等.中老年慢性胃病幽门螺杆菌感染与胃黏膜病理改变的相关性[J].中国老年学杂志，2017，37（18）：4596-4597.
[9]	王娟，杨兵，戴可可，等.幽门螺杆菌感染对慢性乙型肝炎及乙肝肝硬化患者消化道溃疡的临床影响[J].中华医院感染学杂志，2017，27（14）：3200-3203.
[10]	葛航.埃索美拉唑与奥美拉唑三联疗法在2型糖尿病合并胃溃疡中的效果对比探讨[J].糖尿病新世界，2016，19（14）：11-12.
[11]	黄杨清.雷贝拉唑、兰索拉唑及奥美拉唑三联疗法治疗Hp感染消化性胃溃疡临床疗效及安全性分析[J].齐齐哈尔医学院学报，2016，37（19）：2403-2404.
[12]	李魁.吗丁啉、庆大霉素、奥美拉唑三联疗法对慢性胃炎、胃溃疡的疗效影响[J].北方药学，2016，13（6）：102-103.
[13]	向海霞，张高峰.两种三联疗法对胃溃疡患者的疗效对比分析[J].黑龙江医药科学，2016，39（1）：111-112.
[14]	陈庭富，严琦敏，秦明，等.三联疗法治疗幽门螺杆菌感染胃溃疡疗效比较[J].中华医院感染学杂志，2015，25（18）：4183-4185.
[15]	李新征.奥美拉唑阿莫西林联合克拉霉素三联疗法治疗胃溃疡的效果[J].临床医药文献电子杂志，2015，2（31）：6411-6412.