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| Effect of Compound Danshen Dripping Pills combined with Trimetazidine in the treament of chronic congestive heart failure |
| WANG Yong LIANG Yu-ming |
| Department of Internal Pediatric Medicine,People′s Hospital in Yuncheng District of Yunfu City,Guangdong Province,Yunfu 527300,China |
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Abstract Objective To explore and analyze the clinical efficacy of Compound Danshen Dripping Pills combined with Trimetazidine in the treatment of chronic congestive heart failure(CHF)and its influence on the level of high-sensitivity C-reactive protein (hs-CRP).Methods A total of 164 patients with chronic CHF treated in the department of cardiology in our hospital from March 2016 to April 2017 were selected as research objects.They were divided into control group(n=81)and observation group(n=83)according to the random number table method.Basic treatment was provided in both.Besides,Trimetazidine was added in the control group,and Compound Danshen Dripping Pill was used in the observation group on the basis of the control group.The clinical efficacy,changes of hs-CRP and occurrence of adverse reactions were recorded and compared between the two groups.Results At the time of discharge,Lee heart failure score was lower than on admission,the 6-minute walking distance and left ventricular ejection fraction (LVEF)were higher in both groups than those on admission with statistical significance(P＜0.05).Besides,the Lee heart failure score in the observation group was lower than that in the control group,and 6-minute walking distance and left ventricular ejection fraction(LVEF)in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).The hs-CRP levels of both groups after discharge and 1 month after discharge were lower than those on admission,and the hs-CRP level after discharge in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).After 1 month of discharge,there was no statistically significant difference in hs-CRP level between the two groups(P＞0.05).There was no significant difference in the incidence of adverse reactions during treatment between the two groups (P＞0.05).Conclusion Compound Danshen Dripping Pills combined with Trimetazidine obtains a favorable clinical efficacy in the treatment of chronic CHF,and can effectively reduce the level of hs-CRP,which is worthy of clinical application and promotion
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