ObjectiveTo investigate the influence of ozone major autohemotherapy(O-MAHT)on untoward effect related to ischemia reperfusion after angioplasty of lower extremity.Methods75 cases of LEAD patients who had successful endovascular therapy in our hospital from August 2015 to May 2017 were selected as research subjects and divided into 3 groups,25 cases in each group.The patients were treated with O-MAHT three days after angioplasty were included into group A were patients were treated with O-MAHT 12 hours after angioplasty were included into group B;and those had no O-MAHT therapy before and after angioplasty were included into group C.The untoward effect of patients in these three groups after angioplasty was observed and recorded.ResultsThe occurrence rate of untoward effect of patients in group A,group B and group C was 60.0%,64.0%and 88.0%respectively.The group comparison between group A and B regarding the occurrence rate of untoward effect had no statistical difference(P＞0.05);and that between group A and C,group B and C had statistical difference (P＜0.05).ConclusionApplying O-MAHT to patients who had angioplasty of lower extremity atheroselerotic disease before angioplasty and at the early period of postoperation could protect the lower extremity and reduce the untoward effect due to ischemia reperfusion.