直肠癌术后VMAT同期化疗与IMRT同期化疗的急性不良反应比较

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Abstract ObjectiveTo compare the acute adverse reactions of same period chemotherapy of VMAT and IMRT after colorectal cancer surgery,and to explore the clinical application value of the same period VMAT chemotherapy.Methods50 patients with locally advanced rectal cancer(stage T2-T4or N+)from July 2010 to January 2017 in Meizhou People′s Hospital were selected as the research object,according to the different ways of treatment,they were divided into VMAT group(n=20)and IMRT group(n=30).Patients of the VMAT group were given the treatment of VMAT combined with Capecitabine at the same period,patients of the IMRT group were given the treatment of IMRT combined with Capecitabine at the same period.The same chemotherapy regimens of Capecitabine was 825 mg/m2,2 times per day, 5 times per week.Adjuvant chemotherapy for 8-10 times of improved FOLFOX6 scheme.Acute adverse reactions of patients of two groups during treatment,such as skin mucous membrane,digestive tract,urinary tract and hematologic system were compared.ResultsAll patients of the VMAT group completed the operation,and 3 cases of the IMRT group could not tolerate the adverse reactions and terminated the radiation.The most common adverse reactions of patients in the two groups were digestive tract,upper gastrointestinal tract,skin and mucosa reaction and response in sequence;the incidence of levelsⅡ-Ⅳdigestive tract in the IMRT group was significantly higher than that of VMAT group(P<0.05). In the two groups in the reaction of skin mucous membrane,urinary system,upper gastrointestinal tract,and bone marrow suppression such as leukopenia,decreased platelet and anemia had no significant difference (P>0.05).ConclusionPostoperative rectal cancer same period chemotherapy of VMAT combined with Capecitabine has a lower incidence of acute adverse reactions,compared with IMRT combined with Capecitabine can significantly reduce the severe gastrointestinal reaction,and with good tolerance.

Key words： Rectal cancer VMAT IMRT Capecitabine Acute adverse reactions

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	Articles by authors
	LUO Jing
	LI Guo-qiang
	ZHENG Zhi-Jian
	YE Ling XU
	Yu-yun
	LIU Ya-sheng
	YANG Quan-fu

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LUO Jing,LI Guo-qiang,ZHENG Zhi-Jian, et al. Comparison of the acute adverse reactions of same period chemotherapy of VMAT and IMRT after colorectal cancer surgery[J]. 中国当代医药, 2017, 24(11): 71-74转77.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I11/71

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