小儿哮喘患者血清中LncRNA BCYRN1的表达及临床意义

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Abstract ObjectiveTo investigate the expression of serum LncRNA BCYRN1 in children with asthma and the influence on the situation and prognosis.MethodsSerum samples of 120 children with stable asthma from January 2012 to December 2015 in our hospital(including 30 cases of intermittent episodes,30 cases of mild sustained episodes,30 cases of moderate sustained episodes,30 cases of severe persistent episodes)and 30 cases of healthy children as health control were collected.The expression levels of LncRNA BCYRN1 and TNF-α,IL-4,IgE were detected by real-time fluorescence quantitative PCR (qRT-PCR)and the effect of LncRNA BCYRN1 expression on the prognosis were also analyzed.Meanwhile,the relationship between serum LncRNABCYRN1 expression and inflammatory factors IgE,IL-4 and TNF-α were analyzed.ResultsThe expression of LncRNA BCYRN1 in the serum of asthmatic children was significantly higher than that in the children of health control(P<0.05).The expression level of LncRNA BCYRN1 increased gradually with the aggravation of the disease(P<0.05).A positive correlation was also found between LncRNA BCYRN1 expression and inflammatory factors TNF-α,IL-4,IgE (r=0.712,0.770,0.748,all P<0.001).ConclusionThe expression of LncRNA BCYRN1 level associated with children asthma.LncRNA BCYRN1 can be as a predict biomarker of prognosis in children asthma.

Key words： Children asthma LncRNA BCYRN1 Prognosis

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	Articles by authors
	FENG Ming-yu
	WEI Ping
	NI Qiong-xiu
	YANG Ling-rong

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FENG Ming-yu,WEI Ping,NI Qiong-xiu, et al. Expression and clinical significance of LncRNA BCYRN1 in serum of children with asthma[J]. 中国当代医药, 2017, 24(11): 9-12.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I11/9

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