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Effect of application of different ovarian stimulation protocols on women with decreased ovarian reserve functions |
WANG Bin LIANG Jian-di PENG Yu-hong CHEN Hui-nan LIU Zhi-gang MO Yu-qin |
Department of Reproductive Medicine,Dongguan People′s Hospital,Guangdong Province,Dongguan 523000,China |
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Abstract ObjectiveTo study the effect of application of different ovarian stimulation protocols in women with decreased ovarian reserve functions.MethodsAltogether 56 cases of female patients with decreased ovarian reserve functions who were treated in our hospital from June 2015 to May 2016 were selected as the study object and divided into two groups according to the ovarian stimulation protocols;28 patients who underwent ovarian stimulation in the late luteal phase were involved as observation group;while,another 28 patients who underwent short-acting long protocol stimulation were involved as control group.The endometrial thickness,E2level at the day of HCG administration,number of oocytes and the number of high-quality embryos were compared between the two groups.ResultsThe Diphereline usage days, E2level at the day of HCG administration,the number of oocytes and the number of high-quality embryos of observation group were(10.15±0.37)d,(1734.12±165.61)pg/ml,(8.30±1.17)eggs and(4.60±0.82)embryos,significantly better than those of control group[(25.45±1.65)d,(1308.87±143.30)pg/ml,(7.20±0.76)eggs and(2.60±0.50)embryos](P<0.05).There was no statistically significant difference in the LH and P level at the day of HCG administration,endometrial thickness and total Gn between two groups(P>0.05).ConclusionApplication ovarian stimulation at the late stage of luteal phase can improve the number of obtained oocytes,available embryos and high-quality embryos,which can shorten the Diphereline usage days and reduces the cost of treatment.
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