新生儿不同时期血清维生素D对缺氧缺血性脑病诊断价值比较

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Abstract Objective To compare the value of serum vitamin D in different stages of newborns in the diagnosis of hypoxic-ischemic encephalopathy. Methods The clinical data of 90 newborns who was born or delivered in Korla Hospital of the Second Division of Xinjiang Production and Construction Corps from May 2017 to May 2019 were analyzed retrospectively. Healthy newborns were involved as the control group (n=45), and newborns with hypoxic-ischemic encephalopathy were involved as the observation group (n=45). The levels of vitamin D in the two groups were analyzed by enzyme-linked immunosorbent assay at 1 and 7 d after birth. The critical value and the area under the curve of vitamin D in diagnosis of hypoxic-ischemic encephalopathy were compared between the two groups. Results The serum level of vitamin D in the observation group at 1 and 7 d after birth were lower than those in the control group, with statistically significant differences (P＜0.05). The level of vitamin D in the observation group at 7 d after birth was lower than that in the control group, with statistically significant difference (P＜0.05). The area under the curve at 1 and 7 d after birth were 0.681 and 0.703, respectively. The area under the curve at 7 d after birth was better than that at 1 d after birth, with statistically significant difference (Z=1.940, P=0.021). The critical value at 1 and 7 d after birth were 22.5 mmol/L and 21.5 mmol/L,respectively.When the level of vitamin D at 1 d after birth did not exceed 22.5 mmol/L,the specificity and sensitivity of the disease diagnosis were 69.9% and 66.7%, respectively. When the vitamin D level at 7 d after birth was below 21.5 mmol/L, the specificity and sensitivity of disease diagnosis were 73.3% and 80.0%,respectively. Conclusion Vitamin D has high value in the diagnosis of neonatal hypoxic-ischemic encephalopathy. The longer the onset time, the higher the diagnostic value of vitamin D.

Key words： Vitamin D Hypoxic-ischemic encephalopathy Newborn Area under curve Diagnostic threshold

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