Abstract：Objective To compare the gene expression of KRAS, APC and p53 in different subtypes of colorectal lateral developmental tumors (LST), polypoid colorectal adenomas (≥10 mm) and advanced colorectal cancer, and to investigate the molecular pathogenesis of the different subtypes of colorectal lateral developmental tumors.Methods The gene expression of KRAS, APC and p53 in our hospital from January 2016 to July 2018, 38 cases of granular categories(LST-G), 13 cases of nongranular categories (LST-NG), 60 cases of polypoid colorectal adenomas and 48 cases of advanced colorectal cancer were detected by High Resolution Melting (HRM).Results The mutation rate of KRAS, APC and p53 in LST-G group, LST-NG group, polypoid adenoma group and colorectal cancer group were 52.6%, 7.7%,46.7%and 60.4%, 15.8%; 53.8%, 20.0% and 58.3%, 7.9%, 46.2%, 11.7%, and 6.7% respectively.The KRAS mutation rate of LST-NG group were significantly lower than LST-G group, polypoid adenomas group and advanced colorectal cancer group respectively (P<0.05).But there was no significant difference between LST-G group and polypoid adenomas group (P＞0.05).The APC and p53 mutation rate of LST-NG group were significantly higher than LST-G and polypoid adenomas group (P<0.05), whereas the APC and p53 mutation rate were no significant difference between LST-G group and polypoid adenomas group (P＞0.05), the APC and p53 mutation rate in LST-NG group were lower than the advanced colorectal cancer group, but there were no statistically significant difference (P＞0.05).Conclusion The differences of gene expression between LST-G and LST-NG may remind the different molecular pathways.
钟选芳; 黄文峰; 刘宇辉. 不同亚型的大肠侧向发育型肿瘤的KRAS、APC、p53表达[J]. 中国当代医药, 2019, 26(14): 60-62.
ZHONG Xuan-fang; HUANG Wen-feng; LIU Yu-hui. Expression of KRAS，APC and p53 in different subtypes of laterally spreading tumors. 中国当代医药, 2019, 26(14): 60-62.
京公网安备 11010502046607号