Relationship research between cervical lesions and high-risk human papilloma virus load
LIU Ai-min1 HUANG Shu-hui2 YAO Li-feng1 CHEN Yi-ping1
1.Department of Obstetrics and Gynecology，Maternal and Child Health Care Hospital of Pingxiang City in Jiangxi Province，Pingxiang 337055，China；2.Department of Outpatient，Maternal and Child Health Care Hospital of Jiangxi Province，Nanchang 330000，China
Abstract：Objective To explore the relationship between high-risk human papilloma virus （HPV）load and cervical lesions.Methods 3386 patients accepted high-risk HPV viral load detection in gynecological outpatient clinic of our hospital from May 2013 to June 2014 were selected as the research group，931 cases were in positive infection，who were detected with colposcopy，cervical biopsy and endocervical scraping，and pathological examinations further.According to viral load，all of them were divided into group A（viral load from 1 to 100 pg/ml），group B（viral load from 101 to 500 pg/ml），and group C （more than 500 pg/ml）.The situation of cervical lesions was observed among each group.Results A total of 446 cases of cervical lesions were diagnosed.Age and viral load in CINⅠ-Ⅲgroup and cervical cancer group was larger than that in the cervicitis group，with significant difference（P＜0.01）.The composition ratio of cervicitis was gradually decreased with the increase of HPV-DNA virus load，with significant difference （P＜0.01）.The composition ratio of CINⅠ-Ⅲ was gradually increased with the increase of HPV-DNA virus load，with significant difference （P＜0.01）. There was no significant difference in the composition ratio of cervical cancer with different HPV virus load group （P＞0.05）.Conclusion The viral load is closely related with cervical lesions.The older patient′s age becomes，the higher the incidences of cervical tumor-like lesion and cancerization are.
Petry KU，Menton S，Menton M，et al.Inclusion of HPV testing in routine cervical cancer screening for woman above 29 years in Germany：results for 8466 patients［J］.Br J Cancer，2003，88（10）：1570-1577.
Moberg M，Gustavss on I，Gyllensten U.Type-specific associations of human papillomavirus load with risk of developing cervical carcinoma in situ［J］.Int J Cancer，2004，112（5）：854-859.
［7］
Lorincz AT，Castle PE，Sherman ME，et al.Viral load of human papillomavirus and risk of CIN3 or cervical cancer［J］. Lancet，2002，360（9328）：228-229.
［8］
Agorastos T，Diinas K，Lloveras B，et al.Human papilloma virustesting for primary screening in women at low risk of developing cervical cancer.The Green experience［J］.Gynecol Oncol，2005，96（3）：714-720.
Agorastos T，Chatzigeorgiou K，Brotherton JM，et al.Safety of human papillomavirus （HPV）vaccines：a review of the international experience so far［J］.Vaccine，2009，27 （52）：7270-7281.
［12］
Bergeron C，Cas F，Fagnani F，et al.Assessment of human papillomavirus testing on liquid-based cyto-screen system for women with atypical squamous cells of underrmined significance.Effect of age［J］.Gynecol Obstet Fertil，2008，34（4）：312-316.
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