Abstract：Objective To explore the antimicrobial ability of nano-silver/polyurethane-coated endotracheal tube in rats.Methods48 Sprague-Dawley(SD)male rats in SPF grade supplied from Shenzhen PKU-HKUST Medical Center were selected in January 2016.24 healthy rats performed with endotracheal intubation and implanted with nano-silver/polyurethane were coated new antibacterial activity of tracheal catheter were randomly selected as experimental group.During the same period,24 healthy rats performed with endotracheal intubation and inserted common tracheal catheter were selected as control group in random.The clump counted by bronchoalveolar lavage fluid was tested by plate culture counting method 12,24,48 h,and 72 h after surgeries.The biological membrane thickness formed by endotracheal tube in the two groups was observed by microscope.ResultsThere was no great difference in clump count by bronchoalveolar lavage fluid 12 h after surgeries(P＞0.05).In the experimental group,the clump count by bronchoalveolar lavage fluid 24,48 h, and 72 h after surgeries were both much less than those in the control group (P＜0.05).The biological membrane thickness formed by endotracheal tube 12 h and 24 h after surgeries in the experimental group was not displayed statistical difference(P＞0.05).In the experimental group,the biological membrane thickness was formed by endotracheal tube 48 h and 72 h after surgeries were greatly lower than those in the control group(P＜0.05).ConclusionIn comparison with the normal catheter,antimicrobial nano-silver/polyurethane-coated endotracheal tube obtains a stronger antibacterial and anti-biological membrane augmentation properties.
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