| [25] |
Tang Z，Yuan M，Yuanlong HU.The relationship between inactivation of the TGF-β sign-aling pathway and pathogenesis of garstric cancer[J].J Clin Surg，2002.
|
| [27] |
Zhang F，Laiho M.On and off：proteasome and TGF-β signaling[J].Exp Cell Res，2003，291（2）：275-281.
|
| [1] |
Wang YF，Chen HH，Hang SU，et al.Research progress in radiation-induced organfibrosis[J].Milit Med Sci，2016.
|
| [8] |
Massagué J.The TGF-β family of growth and differentiation factors[J].Cell，1987，49（4）：437-438.
|
| [28] |
Kong L，Yao SK，Ying MA.Effect of alteration of TGF-β1/ Smads signaling pathway on pathogenesis of HCC[J].Chin J Clin Hepatol，2007.
|
| [31] |
Kim G，Kim J，Lim YL，et al.Renin-angiotensin system inhibitors and fibrosis in chronicliver disease：a systematic review[J].Hepatol Int，2016（5）：1-10.
|
| [32] |
Porras AM，Hutson HN，Berger AJ，et al.Engineering approaches to study fibrosis in 3-D in vitrosystems[J].Curr Opin Biotechnol，2016，40：24-30.
|
| [2] |
Tan RJ，Zhou D，Liu Y.Signaling Crosstalk between Tubular Epithelial Cells and Interstitial Fibroblasts after Kidney Injury[J].Kidney Dis，2016，2（3）：136.
|
| [3] |
Fujio K，Komai T，Inoue M，et al.Revisiting the regulatory roles of the TGF-β family ofcytokines[J].Autoimmun Rev，2016，15（9）：917-922.
|
| [4] |
Cui Y，Meng Y，Zhang J，et al.Efficient secretory expression of recombinant proteins in Escherichia coli，with a novel actinomycete signal peptide[J].Protein Express Purifi，2017，129：69-74.
|
| [5] |
Weeks DL，Melton DA.A maternal mRNA localized to the vegetal hemisphere Xenopus eggs codes for a growth factor related to TGF-β[J].Cell，1987，51（5）：861-867.
|
| [6] |
Takehara K，Leroy EC，Grotendorst GR.TGF-β inhibition of endothelial cell proliferation：alteration of EGF binding and EGF-induced growth-regulatory（competence）gene expression[J].Cell，1987，49（3）：415-422.
|
| [7] |
Kimelman D，Kirschner M.Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo[J].Cell，1988，51（5）：869.
|
| [9] |
Pohlers D，Brenmoehl J，Loffler I，et al.TGF-beta and fibrosis in different organs-molecular pathway imprints[J].Biochim Biophys Acta，2009，1792（8）：746-756.
|
| [10] |
Gu W，Fukuda T，Isaji T，et al.α1，6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells：the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling[J].Faseb J，2013，27（10）：3947-3958.
|
| [11] |
Johnson LA，Rodansky ES，Sauder KL，et al.Matrix stiffness corresponding to strictured bowel induces a fibrogenic response in human colonic fibroblasts[J].Inflamm Bowel Dis，2013，19（5）：891.
|
| [12] |
Chao Y，Lin W，Bo L，et al.The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis[J].Parasites&Vectors，2015，8（1）：70.
|
| [13] |
Kawecki M，Labus W，Klamabaryla A，et al.A review of decellurization methods caused by an urgent need for quality control of cell-free extracellular matrix′scaffolds and their role in regenerative medicine[J].J Biomed Mater Res B Appl Biomater，2017 March.
|
| [14] |
He L，Sun F，Wang Y，et al.HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE/NF-κB/HPSE signaling to enhance latent TGF-β release from ECM[J].Amer J Transl Res，2016，8（5）：1971.
|
| [15] |
Fang H，Xu G，Yu D.A pathological study on the relationship between TGF-β1、ECM and diabetic nephropathy[J]. Chin J Diabetes，2000.
|
| [16] |
Cui Q，Wang Z，Jiang D，et al.HGF inhibits TGF-β1induced myofibroblast differentiationand ECM deposition via MMP-2 in Achilles tendon in rat.[J].Eur J Appl Physiol，2011，111（7）：1457-1463.
|
| [17] |
Xiao HB，Liu RH，Ling GH，et al.HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1 through ERK1/2 and JNK MAPK pathways[J]. Amer J Physiol Renal Physiol，2012，303（5）：F757.
|
| [18] |
Chen W，Zhong X，Wei Y，et al.TGF-β Regulates Survivin to Affect Cell Cycle and the Expression of EGFR and MMP9 in Glioblastoma[J].Mol Neurobiol，2016，53（3）：1648-1653.
|
| [19] |
Levy L，Hill CS.Alterations in components of the TGF-β superfamily signaling pathways in human cancer[J].Cytokine Growth Factor Rev，2006，17（1-2）：41-58.
|
| [20] |
Pelton RW，Saxena B，Jones M，et al.Immunohistochemical localization of TGFβ1，TGF-β2，and TGF-β3 in the mouse embryo：Expression patterns suggest multiple roles during embryonic development[J].J Cell Biol，1991，115（4）：1091-1105.
|
| [22] |
Yamanaka Y，Gingery A，Oki G，et al.Blocking Fibrotic Signaling in Fibroblasts from Patients with Carpal Tunnel Syndrome[J].J Cell Physiol，2017.
|
| [24] |
Wang M，Wang LR，Hematology D，et al.TGF-β signaling and hematopoietic malignancies[J].Basiccl，2014.
|
| [21] |
Beck LS，Amento EP，Xu Y，et al.TGF-β1 induces bone closure of skull defects：Temporal dynamics of bone forma-tion in defects exposed to rhTGF-β1[J].J Bone Miner Res，2010，8（6）：753-761.
|
| [23] |
Gingery A，Yang TH，Passe SM，et al.TGF-β signaling regulates fibrotic expression and activity in carpal tunnel syndrome[J].J Orthopaed Res，2014，32（11）：1444-1450.
|
| [26] |
Liang YC，Wen-Ting YU，Liang QX，et al.TGF-β1signaling pathway related microRNA regulates metastasis of salivary adenoid cystic carcinoma[J].China J Oral Maxillofac Surg，2014.
|
| [29] |
Wu N，Ge Y，Zhou Y，et al.Nanosized titanium dioxide resulted in the activation of TGF-β/Smads/p38MAPK pathway in renal inflammation and fibration of mice[J].J Biomed Mater Res Part A，2016，104（6）：1452.
|
| [30] |
Dubash AD，Chen YK，Aguado BA，et al.Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes[J].J Cell Biol，2016，213（3）：jcb.201507018.
|
| [33] |
Fan RH，Zhu XM，Sun YW，et al.CTRP6 inhibits fibrogenesis in TGF-β1stimulated human dermal fibroblasts[J]. BiochemBiophysResCommun，2016，475（4）：356.
|
| [34] |
Liu Y.Bone morphogenetic protein-7 inhibits endothelialto-mesenchymal transition in pulmonary artery endothelial cells[J].Chin J Pathophys，2015，15（10）：1-12.
|
| [35] |
Muehlich S，Rehm M，Ebenau A，et al.Synergistic induction of CTGF by cytochalasin Dand TGF-β1in primary human renal epithelial cells：Role of transcriptional regulators MKL1，YAP/TAZ and Smad2/3[J].Cell Signal，2017，29：31-40.
|
| [36] |
Tian S，Li C，Ran R，et al.Surfactant protein A deficiency exacerbates renal interstitial fibrosis following obstructive injury in mice[J].BBA-Mol Basis Dis，2017，1863（2）：509-517.
|
| [37] |
Watanabe J，Takiyama Y，Honjyo J，et al.Role of IGFBP7 in diabetic nephropathy：TGF-β1induces IGFBP7 via Smad2/ 4 in human renal proximal tubular epithelial cells[J].PLoS One，2016，11（3）：e0150897.
|
| [38] |
Torsello B，Bianchi C，Meregalli C，et al.Arg/Abl2 tyrosine kinase modulates TGF-β1production in human renal tubular cells under high glucose condition[J].J Cell Sci，2016，129（15）：jcs.183640.
|
| [39] |
Song Y，Peng C，Lv S，et al.Adipose-derived stem cells ameliorate renal interstitial fibrosis through inhibition of EMT and inflammatory response via TGF-β1signaling pathway[J]. Int Immunopharmacol，2017，44：115.
|
| [40] |
Lee UE，Friedman SL，Friedman SL.Mechanisms of hepatic fibrogenesis[J].Best Practice&Res Clin Gastroenterol，2011，25（2）：195-206.
|
| [41] |
Jin WY，Hien TT，Lim S C，et al.Pin1 induction in the fibrotic liver and its roles in TGF-β1 expression and Smad2/ 3 phosphorylation[J].J Hepatol，2014，60（6）：1235-1241. [42]Liu L，Li XM，Chen L，et al.The Effect of Gypenosides on TGF-β1/Smad Pathway in Liver Fibrosis Induced by Carbon Tetrachloride in Rats[J].Int J Integr Med，2013，1：1.
|
| [43] |
Hasan IH，El-Desouky MA，Hozayen WG，et al.Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-β1/ Smad3 and NF-κB/IκB Pathways[J].Pharmacology，2015，97（1-2）：1.
|
| [44] |
Ning Y，Dang S，Shi J，et al.Caffeic acid phenethyl ester attenuates liver fibrosis via inhibition of TGF-β1/Smad3 pathway and induction of autophagy pathway[J].Biochem Biophys Res Commun，2017.
|
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