加减黄芪健脾汤治疗脾胃虚弱型慢性结肠炎反复发作性腹泻的临床研究

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摘要目的探讨加减黄芪健脾汤治疗脾胃虚弱型慢性结肠炎反复发作性腹泻的临床效果。方法选取2020年12月至2022年8月在大连市中心医院中医内科接受治疗的60例慢性结肠炎患者作为研究对象，采用随机数字表法将其分为治疗组和对照组，每组各30例。治疗组给予加减黄芪健脾汤治疗，对照组给予枯草杆菌二联活菌肠溶胶囊治疗。分别于治疗前及治疗后2、4、8周记录血中T淋巴细胞亚群（CD3+、CD4+）的水平及中医症状积分，并比较两组的临床疗效和停药1个月后复发率。结果治疗组患者治疗后2、4、8周的血中T淋巴细胞亚群（CD3+、CD4+）水平高于对照组，差异有统计学意义（P＜0.05）；治疗组患者治疗后2、4、8周的临床症状总积分低于对照组，差异有统计学意义（P＜0.05）；治疗组患者治疗总有效率高于对照组，差异有统计学意义（P＜0.05）；治疗组患者停药1个月后的复发率低于对照组，差异有统计学意义（P＜0.05）。结论加减黄芪健脾汤治疗脾胃虚弱型慢性结肠炎反复发作性腹泻具有显著疗效，能改善患者的临床症状，还可以提高患者的免疫功能。

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	解则红何丰华▲ 刘玉姿吴晔梁莉婕李舒陈永和洪安婧

关键词 ：加减黄芪健脾汤, 脾胃虚弱型, 慢性结肠炎, 临床研究

Abstract：Objective To investigate the clinical effect of modified Huangqi Jianpi Decoction in treating recurrent diarrhea in chronic colitis of dual deficient of spleen and stomach type. Methods A total of 60 cases of patients with chronic colitis admitted to the Department of Traditional Chinese Medicine (TCM) Internal Medicine of Dalian Central Hospital from December 2020 to August 2022 were selected as subjects. The patients were divided into the treatment group and the control group by random number table method, with 30 cases in each group. The treatment group was given modified Huangqi Jianpi Decoction. The control group was treated with Live Combined Bacillus Subtilis and Enterococcus Faecium Enteric-coated Capsules. The levels of T-lymphocyte subpopulations (CD3+ and CD4+) and TCM symptom scores were recorded before treatment and 2, 4, 8 weeks after treatment. The clinical efficacy and recurrence rate after one month of drug cessation in the two groups were compared. Results The levels of blood T-lymphocyte subpopulations (CD3+ and CD4+) in the treatment group were higher than those in the control group at 2, 4 and 8 weeks after treatment, and the differences were statistically significant (P＜0.05). The total clinical symptom scores of patients in the treatment group were lower than those of the control group at 2, 4 and 8 weeks after treatment, and the differences were statistically significant (P＜0.05). The total effective rate of treatment in the treatment group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The recurrence rate of patients in the treatment group was lower than that of the control group at one month of drug cessation, and the difference was statistically significant (P＜0.05). Conclusion Modified Huangqi Jianpi Decoction in the treatment of recurrent diarrhea of dual deficiency of spleen and stomach type of chronic colitis obtains a significant effect. It can improve the clinical symptoms of the patients, and enhance their immune function.

Key words： Modified Huangqi Jianpi Decoction Dual deficiency of spleen and stomach type Recurrent diarrhea Clinical study

基金资助:[基金项目]辽宁省大连市医学科学研究计划项目（20Z11023）。

通讯作者: ▲通讯作者

作者简介: 解则红（1984-），女，硕士，副主任中医师；研究方向：中医内科学。

引用本文:

解则红何丰华▲ 刘玉姿吴晔梁莉婕李舒陈永和洪安婧. 加减黄芪健脾汤治疗脾胃虚弱型慢性结肠炎反复发作性腹泻的临床研究[J]. 中国当代医药, 2024, 31(1): 98-102.
XIE Zehong HE Fenghua▲ LIU Yuzi WU Ye LIANG Lijie LI Shu CHEN Yonghe HONG Anjing. Clinical study of modified Huangqi Jianpi Decoction in treating recurrent diarrhea in chronic colitis of dual deficient of spleen and stomach type. 中国当代医药, 2024, 31(1): 98-102.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2024/V31/I1/98

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