学龄儿童原发性高尿酸血症早期肾动脉血流与血浆内皮素-1变化关系的研究

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摘要

目的探讨学龄儿童原发性高尿酸血症早期肾动脉血流与血浆内皮素-1变化的关系。方法选取2018年6月～2019年9月在我院进行健康检查的年龄为6～12岁的112例学龄儿童作为研究对象，均进行肾功能、血清尿酸、血浆ET-1 检测及双肾、肾动脉彩色多普勒超声等检查。按照血尿酸值分为高尿酸组（40例）与健康组（72例）；根据高尿酸组的各段肾动脉血流阻力情况，又将其分成肾动脉血流阻力指数（RI）＞0.7组（20例）和RI≤0.7组（20例）。分析学龄儿童原发性高尿酸血症早期肾动脉血流与血浆内皮素-1变化的关系。结果高尿酸组的左肾叶间动脉血流RI 高于健康组，差异有统计学意义（P＜0.01）。高尿酸组的血浆ET-1浓度高于健康组，差异有统计学意义（P＜0.05）。RI＞0.7组的血浆ET-1均值为（212.35±196.52）pg/ml，高于RI≤0.7组的（102.51±46.54）pg/ml，差异有统计学意义（P＜0.05）。结论学龄儿童原发性高尿酸血症可能会引起肾小动脉血流阻力的升高，其可引起血浆ET-1升高，其中以肾动脉血流阻力增高者的ET-1浓度升高较明显，提示学龄儿童的原发性高尿酸血症可引起肾动脉内皮功能紊乱，进而可能引起肾动脉阻力的增高。

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关键词 ：学龄儿童, 原发性高尿酸血症, 肾动脉血流, 血浆内皮素-1, 变化关系

Abstract：

Objective To explore the relationship between the changes of early renal artery hemodynamics and its endothelin-1 (ET-1) of plasma in primary hyperuricemia with school-age children.Methods A total of 112 school-age children (aged 6-12 years old) who had health examination in our hospital from June 2018 to September 2019 were selected as the study subjects.Renal function, serum uricacid, ET-1 of pasma and color Doppler ultrasound of both kidneys and renal arteries were examined.According to the blood uricacid level, they were divided into the hyperuricemia group (40 cases) and the healthy group (72 cases).According to the blood flow resistance of each segment of renal artery, the hyperuricemia group were divided into the resistance index (RI)＞0.7 group (20 cases) and the RI≤0.7 group(20 cases).the relationship between the changes of early renal artery hemodynamics and its ET-1 of plasma in primary Hyperuricemia with school-age children was analyzed.Results The RI of the left interlobular artery in the hyperuricemia group was higher than that in the healthy group, the difference was statistically significant (P＜0.01).The concentration of ET-1 of plasma of the hyperuricemia group was higher than that of the healthy group, the difference was statistically significant (P＜0.05).The mean value of ET-1 of plasma in the RI＞0.7 group was (212.35±196.52) pg/ml,which was higher than that in the RI ≤0.7 group ([102.51±46.54]pg/ml), the difference was statistically significant(P＜0.05).Conclusion Primary hyperuricemia in schoolage children may cause the increase of renal arteriole blood flow resistance, which may cause the increase of ET-1 of plasma.The increase of ET-1 concentration in those with increased renal arteriole blood flow resistance is more obvious, which suggests that primary hyperuricemia in school-age children may cause the disorder of renal arteriole inner skin function, and then may cause the increase of renal arteriole resistance

Key words： School-age children Primary hyperuricemia Renal artery hemodynamics Endothelin-1 of plasma Variation relation

基金资助:

广东省广州市番禺区科技计划项目（2018-Z04-11）

作者简介: 程远（1981-），女，硕士，主治医师，研究方向：儿童超声

引用本文:

程远；黄洁兴；陈惠清；黄向晖. 学龄儿童原发性高尿酸血症早期肾动脉血流与血浆内皮素-1变化关系的研究[J]. 中国当代医药, 2020, 27(20): 164-167.
CHENG Yuan1 HUANG Jie-xing2 CHEN Hui-qing1 HUANG Xiang-hui2. Study on the relationship between the changes of early renal artery hemodynamics and its endothelin-1 of plasma in primary hyperuricemia with school-age children. 中国当代医药, 2020, 27(20): 164-167.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I20/164

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