Abstract:Objective To investigate the effect of Tacrolimus combined with low-dose glucocorticoid in the treatment of nephrotic syndrom. Methods A total of 100 patients with nephrotic syndrome admitted to Iron Coal General Hospital of Liaoning Health Industry Group from January to June 2020 were selected as the research objects. They were divided into observation group (50 cases) and control group (50 cases) according to the random lottery method. The observation group was treated with Tacrolimus and low-dose glucocorticoid, while the control group was treated with low-dose glucocorticoid. The therapeutic effect, adverse reactions and renal function indexes of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, and the total incidence of adverse reactions was lower than that of the control group, the differences were statistically significant (P<0.05). After treatment, the serum albumin of the observation group was higher than that of the control group, and the urea nitrogen,creatinine and 24-hours urinary albumin of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). Conclusion Tacrolimus combined low-dose glucocorticoid is effective in the treatment of nephrotic syndrome, which can improve the renal function of patients.
谭静. 他克莫司联合小剂量糖皮质激素治疗肾病综合征的效果[J]. 中国当代医药, 2021, 28(19): 134-136.
TAN Jing. Effect of Tacrolimus combined with low-dose glucocorticoid in the treatment of nephrotic syndrome. 中国当代医药, 2021, 28(19): 134-136.
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